Well, the only insight I can offer you is into speed. I recently had to downgrade my laptop's harddrive (long story), so currently it isn't big enough for VMWare. So I copied my virtual machines to an ext3 partition on a USB harddrive (which I'm connected to on USB 1.1). I figured I'd give VMWare a shot to see how it would run, and, as far as I can tell, it ran absolutely the same as when I had it on my regular harddrive.
So in terms of speed, VMWare isn't picky.