I don't use a mousepad, and I don't really use my mouse much. Just when I have to. Most of the time I know all the shortcuts and editor commands so the only time I use a mouse is when I'm browsing online. Plus, I normally use a touchpad, I normally lose my mouse around my bedroom and just forget to use it.
I actually have mine plugged in today, though, because I was trying Quake 2 (Jake2, actually). No mousepad